About Gene List

PF3D7_0609000 (NUP637)

Genome location: Pf3D7_06_v3:369,043..388,626(+)

Genome classification: Core

Function and Localization

Product Description: nucleoporin NUP637, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0034399 nuclear periphery
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 1.77 0.32
Trophozoite expressed 2.45 0.11
Schizont expressed 1.86 0.26
Gametocyte expressed 2.08 0.17

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0609000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.774 | MFS: -3.061 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0107600)

Modification: Tagged | RMgm-5243

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533540

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 75 264 127 310
disruptive 307 750 401 923
missense 153 512 292 675

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 130 453 224 357
disruptive 504 1419 661 1452
missense 251 950 488 938

PlasmoDB Total SNPs: 745

Non-coding: 102 | Synonymous: 371 | Nonsynonymous: 272 | Stop Codon: 0

Protein Information

Protein Length: 6077 | Molecular Weight (kDa): 720.514

UniProt ID(s): C6KST7

PDB ID(s): None

Isoelectric Point: 7

Protein Domain Annotations:

Source Family ID Description
InterPro IPR040163 RP1/RP1L1/DCX
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
36040030 TurboID Identification of Evolutionarily Divergent Components of the Nuclear PoreComplex in the Malaria Model Plasmodium berghei. Ambekar SV, Beck JR, Mair GR 10.1128/mbio.01815-22