Product Description: zinc transporter ZIP1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 8
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Function | GO:0005385 | zinc ion transmembrane transporter activity |
| Process | GO:0071577 | zinc ion transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.11 | 0.94 |
| Trophozoite | expressed | 0.08 | 0.95 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.49 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0609100
Resistome Missense Mutations: L308P
Resistome Compounds with Missense Mutations: MMV008434
Resistome # Samples with Disruptive Mutations: 4 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.703 | MFS: -2.268 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0107700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_0107700)
Modification: Tagged | RMgm-4348
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KST8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100840
Most Similar Human Ortholog: K7ENJ1
TM-align score: 0.74 | RMSD: 2.45
Seq Identity: 0.23 | Length: 105 / 358
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000141873 | solute carrier family 39 member 3 |
| ENSG00000143570 | solute carrier family 39 member 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 1 | 2 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 3 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 334
Non-coding: 292 | Synonymous: 22 | Nonsynonymous: 18 | Stop Codon: 2
Protein Length: 358 | Molecular Weight (kDa): 40.259
UniProt ID(s): C6KST8
PDB ID(s): None
Isoelectric Point: 7.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003689 | Zinc/iron permease |
| PFam | PF02535 | Zinc/iron permease |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 38163252 | Plasmodium falciparum ZIP1 Is a Zinc-Selective Transporter with Stage-DependentTargeting to the Apicoplast and Plasma Membrane in Erythrocytic Parasites | Shrivastava D, Jha A, ..., Habib S | 10.1021/acsinfecdis.3c00426 |
| 36814598 | Kinetic analysis of synaptonemal complex dynamics during meiosis of yeastSaccharomyces cerevisiae reveals biphasic growth and abortive disassembly | Pollard MG, Rockmill B, ..., Fung JC | 10.3389/fcell.2023.1098468 |