PF3D7_0609300

Genome location: Pf3D7_06_v3:396,165..399,337(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	possibly expressed	0.42	0.75
Schizont	possibly expressed	0.14	0.91
Gametocyte	not expressed	0.94	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0609300

Resistome Missense Mutations: H65N

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.144 | MFS: -2.771 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSU0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532779

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	25	20	55
disruptive	69	135	82	213
missense	42	106	58	178

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	67	44	65
disruptive	106	304	128	269
missense	57	231	95	184

PlasmoDB Total SNPs: 146

Non-coding: 12 | Synonymous: 74 | Nonsynonymous: 60 | Stop Codon: 0

Protein Information

Protein Length: 987 | Molecular Weight (kDa): 118.591

UniProt ID(s): C6KSU0

PDB ID(s): None

Isoelectric Point: 7.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104