PF3D7_0609500

Genome location: Pf3D7_06_v3:402,722..407,242(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MRLFFLFSMFLIKCATS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0609500

Resistome Missense Mutations: S297F, D803N

Resistome Compounds with Missense Mutations: DSM1, Suloctidil

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.971 | MFS: -2.682 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSU2

"Best" AlphaFill ligand hit: PAL (n-(phosphonacetyl)-l-aspartic acid, Local RMSD=7.11) with 4BJH (Global RMSD=14.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532386

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	42	24	50
disruptive	10	55	37	110
missense	10	53	37	103

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	84	39	56
disruptive	23	145	88	165
missense	18	124	82	131

PlasmoDB Total SNPs: 179

Non-coding: 121 | Synonymous: 48 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 1067 | Molecular Weight (kDa): 126.92

UniProt ID(s): C6KSU2

PDB ID(s): None

Isoelectric Point: 8.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A