PF3D7_0609600

Genome location: Pf3D7_06_v3:408,041..412,002(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.03	0.98
Trophozoite	expressed	0.14	0.92
Schizont	expressed	0.18	0.89
Gametocyte	expressed	0.44	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0609600

Resistome Missense Mutations: F10V, R442K

Resistome Compounds with Missense Mutations: Desoxyepothilone B, MMV665794

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.98 | MFS: -2.731 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSU3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532477

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	49	25	66
disruptive	45	127	100	208
missense	39	100	91	169

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	93	50	86
disruptive	77	323	136	333
missense	53	253	107	238

PlasmoDB Total SNPs: 156

Non-coding: 30 | Synonymous: 75 | Nonsynonymous: 51 | Stop Codon: 0

Protein Information

Protein Length: 1257 | Molecular Weight (kDa): 151.593

UniProt ID(s): C6KSU3

PDB ID(s): None

Isoelectric Point: 9.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A