PF3D7_0609700 (KIC6)

Genome location: Pf3D7_06_v3:412,443..420,258(+)

Genome classification: Core

Function and Localization

Product Description: protein KIC6

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	2.04	0.29
Trophozoite	expressed	0.58	0.71
Schizont	expressed	1.64	0.33
Gametocyte	expressed	1.14	0.44

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0609700

Resistome Missense Mutations: S1127R

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 9 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.368 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0108200)

Relative Growth Rate: 0.56 ± 0.18
Confidence: 4.85

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0108200)

Modification: Disrupted | RMgm-1646

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSU4

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=10.30) with 4XHP (Global RMSD=36.21)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532994

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	22	84	48	123
disruptive	85	227	125	331
missense	48	170	101	275

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	188	65	116
disruptive	156	497	207	453
missense	79	374	170	326

PlasmoDB Total SNPs: 411

Non-coding: 177 | Synonymous: 119 | Nonsynonymous: 114 | Stop Codon: 1

Protein Information

Protein Length: 1901 | Molecular Weight (kDa): 225.1

UniProt ID(s): C6KSU4

PDB ID(s): None

Isoelectric Point: 6.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104