PF3D7_0609900

Genome location: Pf3D7_06_v3:423,862..432,332(+)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0000127	transcription factor TFIIIC complex
Process	GO:0006383	transcription by RNA polymerase III

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.42	0.80
Trophozoite	not expressed	0.41	0.76
Schizont	not expressed	0.57	0.68
Gametocyte	not expressed	0.50	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0609900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.986 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSU6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533346

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	72	43	101
disruptive	62	164	115	276
missense	32	127	100	231

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	135	64	100
disruptive	98	426	233	465
missense	44	316	179	297

PlasmoDB Total SNPs: 410

Non-coding: 187 | Synonymous: 149 | Nonsynonymous: 74 | Stop Codon: 0

Protein Information

Protein Length: 2017 | Molecular Weight (kDa): 244.672

UniProt ID(s): C6KSU6

PDB ID(s): None

Isoelectric Point: 6.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR039340	Transcription factor Tfc4/TFIIIC-102/Sfc4
PFam	N/A	N/A
Superfamily	SSF81901	N/A