Product Description: ribosomal protein L19, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.03 | 0.99 |
| Trophozoite | no data | 0.33 | 0.79 |
| Schizont | no data | 0.09 | 0.93 |
| Gametocyte | no data | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0610000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.132 | MFS: -2.88 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSU7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101282
Most Similar Human Ortholog: S4R3W9
TM-align score: 0.55 | RMSD: 3.09
Seq Identity: 0.24 | Length: 93 / 313
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115364 | mitochondrial ribosomal protein L19 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 18 | 10 | 24 |
| disruptive | 0 | 8 | 12 | 20 |
| missense | 0 | 8 | 12 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 35 | 10 | 23 |
| disruptive | 3 | 26 | 28 | 58 |
| missense | 2 | 18 | 25 | 47 |
PlasmoDB Total SNPs: 76
Non-coding: 63 | Synonymous: 11 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 313 | Molecular Weight (kDa): 38.252
UniProt ID(s): C6KSU7
PDB ID(s): None
Isoelectric Point: 10.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001857 | Ribosomal protein L19 |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| PFam | PF01245 | Ribosomal protein L19 |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |