PF3D7_0610100 (SLU7)

Genome location: Pf3D7_06_v3:434,240..436,684(-)

Genome classification: Core

Function and Localization

Product Description: pre-mRNA-splicing factor SLU7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005681	spliceosomal complex
Process	GO:0008380	RNA splicing
Process	GO:0000375	RNA splicing, via transesterification reactions
Process	GO:0000350	generation of catalytic spliceosome for second transesterification step

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.56	0.73
Trophozoite	expressed	0.66	0.63
Schizont	expressed	0.24	0.85
Gametocyte	expressed	0.56	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0610100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.302 | MFS: -2.921 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSU8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101940

Most Similar Human Ortholog: A0A0C4DGD2

TM-align score: 0.46 | RMSD: 3.65

Seq Identity: 0.46 | Length: 68 / 444

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000164609	SLU7 homolog, splicing factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	17	15	26
disruptive	7	26	26	51
missense	4	24	19	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	37	13	30
disruptive	22	76	35	105
missense	7	53	28	77

PlasmoDB Total SNPs: 146

Non-coding: 119 | Synonymous: 20 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 444 | Molecular Weight (kDa): 53.016

UniProt ID(s): C6KSU8

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR021715	Pre-mRNA-splicing factor SLU7 domain
InterPro	IPR039974	Pre-mRNA-splicing factor SLU7
PFam	PF11708	Pre-mRNA-splicing factor SLU7 domain
Superfamily	N/A	N/A