Product Description: RNA-binding protein 25, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.56 | 0.74 |
| Trophozoite | no data | 0.92 | 0.52 |
| Schizont | no data | 0.27 | 0.84 |
| Gametocyte | no data | 0.80 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0610200
Resistome Missense Mutations: D586N
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.642 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0108700)
Modification: Disrupted | RMgm-1647
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSU9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103133
Most Similar Human Ortholog: E9PQU5
TM-align score: 0.54 | RMSD: 3.39
Seq Identity: 0.20 | Length: 155 / 960
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000119707 | RNA binding motif protein 25 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 30 | 22 | 51 |
| disruptive | 52 | 110 | 68 | 209 |
| missense | 25 | 73 | 50 | 162 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 72 | 33 | 53 |
| disruptive | 94 | 297 | 151 | 278 |
| missense | 36 | 200 | 104 | 174 |
PlasmoDB Total SNPs: 211
Non-coding: 59 | Synonymous: 92 | Nonsynonymous: 60 | Stop Codon: 0
Protein Length: 960 | Molecular Weight (kDa): 115.744
UniProt ID(s): C6KSU9
PDB ID(s): None
Isoelectric Point: 4.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR002483 | PWI domain |
| InterPro | IPR034268 | RBM25, RNA recognition motif |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| InterPro | IPR036483 | PWI domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| PFam | PF01480 | PWI domain |
| Superfamily | SSF101233 | PWI domain superfamily |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |