PF3D7_0610700

Genome location: Pf3D7_06_v3:452,476..453,446(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.38	0.81
Trophozoite	possibly expressed	0.28	0.83
Schizont	expressed	0.08	0.95
Gametocyte	not expressed	0.24	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0610700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.151 | MFS: -2.902 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSV2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533260

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	2	2	4
disruptive	3	3	11
missense	3	3	7

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	6	3	4
disruptive	1	16	7	12
missense	0	11	7	9

PlasmoDB Total SNPs: 55

Non-coding: 47 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 87 | Molecular Weight (kDa): 10.149

UniProt ID(s): C6KSV2

PDB ID(s): None

Isoelectric Point: 5.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A