PF3D7_0611000

Genome location: Pf3D7_06_v3:463,021..465,127(-)

Genome classification: Core

Function and Localization

Product Description: SNARE associated Golgi protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.01	1.00
Trophozoite	possibly expressed	0.11	0.92
Schizont	possibly expressed	0.09	0.93
Gametocyte	possibly expressed	0.31	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0611000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.393 | MFS: -0.763 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0109300)

Modification: Tagged | RMgm-711

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSV5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102890

Most Similar Human Ortholog: Q5BJD5

TM-align score: 0.70 | RMSD: 2.76

Seq Identity: 0.20 | Length: 230 / 287

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000166471	transmembrane protein 41B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	10	6	13
disruptive	0	11	7	18
missense	0	10	7	13

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	22	10	17
disruptive	4	30	13	41
missense	1	18	11	27

PlasmoDB Total SNPs: 83

Non-coding: 72 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 287 | Molecular Weight (kDa): 33.325

UniProt ID(s): C6KSV5

PDB ID(s): None

Isoelectric Point: 10.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR032816	SNARE associated Golgi protein
PFam	PF09335	SNARE associated Golgi protein
Superfamily	N/A	N/A