About Gene List

PF3D7_0611100 (SDH3)

Genome location: Pf3D7_06_v3:466,047..466,537(-)

Genome classification: Core

Function and Localization

Product Description: succinate dehydrogenase subunit 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: 1.3.5.1 (Succinate dehydrogenase (quinone))

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.01 1.00
Trophozoite no data 0.09 0.94
Schizont no data 0.07 0.95
Gametocyte no data 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0611100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.15 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0109400)

  • Relative Growth Rate: 0.94 ± 0.19
  • Confidence: 4.75

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0109400)

Modification: Disrupted | RMgm-1652

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSV6

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
1.3.5.1 succinate dehydrogenase oxalateMaleatefumaratemalonaterotenonecarboxinsiccaninboscalidfenfurammepronilclozapinebenodanil...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215333

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 5 5 4
disruptive 0 2 0 1
missense 0 1 0 1

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 12 2 3
disruptive 0 3 0 10
missense 0 2 0 8

PlasmoDB Total SNPs: 18

Non-coding: 16 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 83 | Molecular Weight (kDa): 9.562

UniProt ID(s): C6KSV6

PDB ID(s): None

Isoelectric Point: 4.75

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
32591483 Conserved regions of budding yeast Tim22 have a role in structural organizationof the carrier translocase Kumar A, Matta SK, D'Silva P 10.1242/jcs.244632
28910984 Genomic and transcriptomic analysis of Saccharomyces cerevisiae isolates withfocus in succinic acid production Franco-Duarte R, Bessa D, ..., Pais C 10.1093/femsyr/fox057