Genome location: Pf3D7_06_v3:467,227..469,157(+)
Genome classification: Core
Product Description: AP2 domain transcription factor AP2-EXP2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0034399 | nuclear periphery |
| Function | GO:0003700 | DNA-binding transcription factor activity |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.06 | 0.97 |
| Trophozoite | no data | 0.55 | 0.68 |
| Schizont | no data | 0.12 | 0.92 |
| Gametocyte | no data | 0.49 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0611200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.828 | MFS: -2.697 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0109500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0109500)
Modification: Disrupted | RMgm-1653
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSV7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 12 | 8 | 9 |
| disruptive | 1 | 15 | 9 | 17 |
| missense | 1 | 14 | 7 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 27 | 8 | 11 |
| disruptive | 4 | 37 | 19 | 48 |
| missense | 2 | 24 | 14 | 35 |
PlasmoDB Total SNPs: 97
Non-coding: 87 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 278 | Molecular Weight (kDa): 34.304
UniProt ID(s): C6KSV7
PDB ID(s): None
Isoelectric Point: 9.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001471 | AP2/ERF domain |
| PFam | PF00847 | AP2/ERF domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35083215 | PfAP2-EXP2, an Essential Transcription Factor for the IntraerythrocyticDevelopment of Plasmodium falciparum. | Shang X, Wang C, ..., Jiang M | 10.3389/fcell.2021.782293 |