Product Description: ATP synthase-associated protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.01 | 0.99 |
| Trophozoite | no data | 0.12 | 0.92 |
| Schizont | no data | 0.02 | 0.99 |
| Gametocyte | no data | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0611300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.244 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0109600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0109600)
Modification: Tagged | RMgm-4964
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSV8
"Best" AlphaFill ligand hit: STU (staurosporine, Local RMSD=3.54) with 4MVF (Global RMSD=26.00)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 12 | 4 | 9 |
| disruptive | 1 | 8 | 5 | 20 |
| missense | 1 | 8 | 4 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 10 | 11 |
| disruptive | 4 | 22 | 14 | 38 |
| missense | 2 | 16 | 12 | 20 |
PlasmoDB Total SNPs: 39
Non-coding: 30 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 280 | Molecular Weight (kDa): 33.476
UniProt ID(s): C6KSV8
PDB ID(s): None
Isoelectric Point: 9.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27594426 | A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes. | Sidik SM, Huet D, ..., Lourido S | 10.1016/j.cell.2016.08.019 |
| 30005062 | Highly diverged novel subunit composition of apicomplexan F-type ATP synthaseidentified from Toxoplasma gondii. | Salunke R, Mourier T, ..., Shanmugam D | 10.1371/journal.pbio.2006128 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |