Product Description: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Process | GO:0010468 | regulation of gene expression |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.30 | 0.85 |
| Trophozoite | possibly expressed | 0.33 | 0.80 |
| Schizont | not expressed | 0.12 | 0.91 |
| Gametocyte | not expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0611400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.954 | MFS: -2.821 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0109700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0109700)
Modification: Disrupted | RMgm-1655
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSV9
"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=0.54) with 5AIV (Global RMSD=15.50)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100964
Most Similar Human Ortholog: F8VRQ4
TM-align score: 0.54 | RMSD: 4.32
Seq Identity: 0.18 | Length: 214 / 830
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000066117 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 |
| ENSG00000082014 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
| ENSG00000108604 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 22 | 8 | 39 |
| disruptive | 10 | 55 | 23 | 98 |
| missense | 4 | 54 | 23 | 88 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 41 | 20 | 54 |
| disruptive | 19 | 115 | 67 | 131 |
| missense | 7 | 102 | 62 | 98 |
PlasmoDB Total SNPs: 51
Non-coding: 21 | Synonymous: 20 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 830 | Molecular Weight (kDa): 97.79
UniProt ID(s): C6KSV9
PDB ID(s): None
Isoelectric Point: 4.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003121 | SWIB/MDM2 domain |
| InterPro | IPR019835 | SWIB domain |
| InterPro | IPR036885 | SWIB/MDM2 domain superfamily |
| PFam | PF02201 | SWIB/MDM2 domain |
| Superfamily | SSF47592 | SWIB/MDM2 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 26791088 | Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues. | Vieira WA, Coetzer TL | 10.1186/s12936-015-1065-9 |
| 32019597 | PfSWIB, a potential chromatin regulator for var gene regulation and parasitedevelopment in Plasmodium falciparum. | Wang WF, Zhang YL | 10.1186/s13071-020-3918-5 |