PF3D7_0611500

Genome location: Pf3D7_06_v3:482,825..483,907(-)

Genome classification: Core

Function and Localization

Product Description: EF hand domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0611500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.506 | MFS: -2.827 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0109800)

Modification: Tagged | RMgm-4951

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSW0

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=2.70) with 6JWR (Global RMSD=19.81)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148525

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 13

Non-coding: 0 | Synonymous: 11 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 360 | Molecular Weight (kDa): 43.035

UniProt ID(s): C6KSW0

PDB ID(s): None

Isoelectric Point: 6.69

Protein Domain Annotations: