About Gene List

PF3D7_0611600 (BTP1)

Genome location: Pf3D7_06_v3:484,649..487,474(-)

Genome classification: Core

Function and Localization

Product Description: basal complex transmembrane protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045178 basal part of cell
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.18 0.91
Trophozoite no data 0.41 0.78
Schizont no data 1.19 0.48
Gametocyte no data 0.92 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0611600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.171 | MFS: -2.78 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSW1

"Best" AlphaFill ligand hit: A2P (adenosine-2'-5'-diphosphate, Local RMSD=0.73) with 2OK7 (Global RMSD=26.40)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532988

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 25 18 35
disruptive 12 51 40 98
missense 11 49 35 87

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 56 28 34
disruptive 25 130 68 130
missense 19 103 58 103

PlasmoDB Total SNPs: 110

Non-coding: 66 | Synonymous: 26 | Nonsynonymous: 17 | Stop Codon: 1

Protein Information

Protein Length: 650 | Molecular Weight (kDa): 76.664

UniProt ID(s): C6KSW1

PDB ID(s): None

Isoelectric Point: 9.77

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
26763910 Pellicle formation in the malaria parasite. Kono M, Heincke D, ..., Gilberger TW 10.1242/jcs.181230
28578947 Structural characterization and immunomodulatory activity of a water solublepolysaccharide isolated from Botrychium ternatum Zhao X, Li J, ..., Pan Y 10.1016/j.carbpol.2017.05.014
25586744 A BTP1 prophage gene present in invasive non-typhoidal Salmonella determinescomposition and length of the O-antigen of the lipopolysaccharide Kintz E, Davies MR, ..., van der Woude MW 10.1111/mmi.12933