About Gene List

PF3D7_0611700 (RPL39)

Genome location: Pf3D7_06_v3:488,418..489,504(-)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L39

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.12 0.94
Trophozoite no data 0.16 0.89
Schizont no data 0.03 0.98
Gametocyte no data 0.09 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0611700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.157 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0110000)

  • Relative Growth Rate: 0.62 ± 0.19
  • Confidence: 4.72

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0110000)

Modification: Disrupted | RMgm-1656

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4H3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101109

Most Similar Human Ortholog: P62891

TM-align score: 0.94 | RMSD: 1.13

Seq Identity: 0.65 | Length: 51 / 51

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000163923 ribosomal protein L39 like
ENSG00000198918 ribosomal protein L39

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 68

Non-coding: 66 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 51 | Molecular Weight (kDa): 6.519

UniProt ID(s): C0H4H3

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 12.66

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000077 Ribosomal protein L39e
InterPro IPR020083 Ribosomal protein L39e, conserved site
InterPro IPR023626 Ribosomal protein L39e domain superfamily
PFam PF00832 Ribosomal protein L39e
Superfamily SSF48662 Ribosomal protein L39e domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
24072706 Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, andRpl39 of Saccharomyces cerevisiae Zhang Y, Wolfle T, Rospert S 10.1074/jbc.M113.508283