About Gene List

PF3D7_0611800

Genome location: Pf3D7_06_v3:490,750..501,967(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 1.10 0.55
Trophozoite not expressed 1.38 0.37
Schizont possibly expressed 0.91 0.52
Gametocyte not expressed 1.65 0.29

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0611800

Resistome Missense Mutations: E2243K

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 3 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.635 | #Insertions: 39

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0110100)

Modification: Disrupted | RMgm-1657

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106613

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 25 92 53 140
disruptive 184 452 212 561
missense 87 303 155 403

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 45 173 103 190
disruptive 306 877 438 993
missense 145 595 309 599

PlasmoDB Total SNPs: 546

Non-coding: 122 | Synonymous: 266 | Nonsynonymous: 158 | Stop Codon: 0

Protein Information

Protein Length: 3248 | Molecular Weight (kDa): 374.892

UniProt ID(s): C6KSW2, Q95Z20

PDB ID(s): None

Isoelectric Point: 5.58

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF141571 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108