PF3D7_0611900

Genome location: Pf3D7_06_v3:505,314..507,593(+)

Genome classification: Core

Function and Localization

Product Description: lsm12, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.03	0.99
Trophozoite	no data	0.13	0.92
Schizont	no data	0.02	0.98
Gametocyte	no data	0.38	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0611900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.869 | MFS: -2.108 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSW3

"Best" AlphaFill ligand hit: 5GP (guanosine-5'-monophosphate, Local RMSD=2.51) with 6I0M (Global RMSD=17.28)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103238

Most Similar Human Ortholog: Q3MHD2

TM-align score: 0.55 | RMSD: 4.33

Seq Identity: 0.26 | Length: 136 / 176

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000161654	LSM12 homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	7	5	9
disruptive	0	4	4	10
missense	0	4	4	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	16	8	6
disruptive	2	22	19	34
missense	1	17	13	24

PlasmoDB Total SNPs: 83

Non-coding: 79 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 176 | Molecular Weight (kDa): 20.265

UniProt ID(s): C6KSW3

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019181	Anticodon-binding domain
InterPro	IPR039683	Protein Lsm12-like
PFam	PF09793	Anticodon-binding domain
Superfamily	N/A	N/A