PF3D7_0612000

Genome location: Pf3D7_06_v3:506,386..508,412(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.04	0.97
Schizont	no data	0.04	0.97
Gametocyte	no data	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0612000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.196 | MFS: -2.485 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0110300)

Relative Growth Rate: 0.17 ± 0.25
Confidence: 4.14

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSW4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179331

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	6	1	8
disruptive	4	4	7
missense	4	4	7

Any inclusion in genotype call

variant type	rare	doubleton	singleton
synonymous	12	2	4
disruptive	9	13	18
missense	8	12	13

PlasmoDB Total SNPs: 69

Non-coding: 65 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 84 | Molecular Weight (kDa): 10.245

UniProt ID(s): C6KSW4

PDB ID(s): None

Isoelectric Point: 9.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A