Product Description: eukaryotic translation initiation factor 3 subunit L, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.59 | 0.72 |
| Trophozoite | no data | 0.81 | 0.56 |
| Schizont | no data | 0.21 | 0.86 |
| Gametocyte | no data | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0612100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.905 | #Insertions: 3
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0110400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0110400)
Modification: Disrupted | RMgm-1659
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSW5
"Best" AlphaFill ligand hit: UD2 ((2r,3r,4r,5r,6r)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl [(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, Local RMSD=1.88) with 6EJI (Global RMSD=24.01)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102359
Most Similar Human Ortholog: B0QY90
TM-align score: 0.83 | RMSD: 3.36
Seq Identity: 0.28 | Length: 434 / 656
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100129 | eukaryotic translation initiation factor 3 subunit L |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 22 | 22 | 36 |
| disruptive | 44 | 42 | 24 | 58 |
| missense | 7 | 23 | 17 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 68 | 17 | 37 |
| disruptive | 55 | 97 | 58 | 144 |
| missense | 14 | 51 | 41 | 86 |
PlasmoDB Total SNPs: 135
Non-coding: 92 | Synonymous: 25 | Nonsynonymous: 18 | Stop Codon: 0
Protein Length: 656 | Molecular Weight (kDa): 78.129
UniProt ID(s): C6KSW5
PDB ID(s): None
Isoelectric Point: 8.32
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019382 | Translation initiation factor 3 complex subunit L |
| PFam | PF10255 | Translation initiation factor 3 complex subunit L |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |