About Gene List

PF3D7_0612200 (LRR6)

Genome location: Pf3D7_06_v3:512,392..519,614(-)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000781 chromosome, telomeric region
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Function GO:0019901 protein kinase binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.12 0.94
Trophozoite expressed 0.89 0.59
Schizont expressed 1.44 0.41
Gametocyte expressed 1.39 0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0612200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.177 | MFS: -2.742 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSW6

"Best" AlphaFill ligand hit: PRL (proflavin, Local RMSD=0.11) with 1QVT (Global RMSD=38.36)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533135

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 64 33 99
disruptive 102 196 87 277
missense 53 146 67 209

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 130 63 98
disruptive 161 362 191 415
missense 73 260 151 289

PlasmoDB Total SNPs: 397

Non-coding: 167 | Synonymous: 140 | Nonsynonymous: 90 | Stop Codon: 0

Protein Information

Protein Length: 1864 | Molecular Weight (kDa): 220.294

UniProt ID(s): C6KSW6, Q1L6A2

PDB ID(s): None

Isoelectric Point: 5.48

Protein Domain Annotations:

Source Family ID Description
InterPro IPR025875 Leucine rich repeat 4
PFam PF12799 Leucine rich repeat 4
Superfamily SSF52058 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
28376558 Pf AP2Tel, harbouring a non-canonical D NA-binding A P2 domain, binds to Plasmodiumfalciparum telomeres Sierra-Miranda M, Vembar SS, ..., Hernandez-Rivas R 10.1111/cmi.12742