PF3D7_0612300 (TMEM234)

Genome location: Pf3D7_06_v3:520,410..521,138(+)

Genome classification: Core

Function and Localization

Product Description: transmembrane protein 234, putative

SignalP Peptide: MYFFLYLIIGILWGCTNA

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.03	0.98
Schizont	no data	0.04	0.97
Gametocyte	no data	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0612300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.129 | MFS: -2.944 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSW7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104697

Most Similar Human Ortholog: Q8WY98

TM-align score: 0.75 | RMSD: 2.78

Seq Identity: 0.28 | Length: 115 / 118

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000160055	transmembrane protein 234

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	4	3	10
disruptive	1	10	2	15
missense	1	10	2	11

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	9	7	12
disruptive	2	26	8	23
missense	1	19	7	14

PlasmoDB Total SNPs: 39

Non-coding: 38 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 118 | Molecular Weight (kDa): 13.83

UniProt ID(s): C6KSW7

PDB ID(s): None

Isoelectric Point: 8.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018908	Putative transmembrane family 234
PFam	PF10639	Putative transmembrane family 234
Superfamily	SSF103481	N/A