PF3D7_0612500

Genome location: Pf3D7_06_v3:522,300..522,665(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.02	0.98
Schizont	no data	0.02	0.99
Gametocyte	no data	0.74	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0612500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.256 | MFS: -2.514 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSW8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533492

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	3	1	5
disruptive	1	8	9	12
missense	1	8	9	10

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	5	2	9
disruptive	3	20	18	20
missense	3	17	18	14

PlasmoDB Total SNPs: 3

Non-coding: 0 | Synonymous: 0 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 121 | Molecular Weight (kDa): 14.137

UniProt ID(s): C6KSW8

PDB ID(s): None

Isoelectric Point: 8.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A