About Gene List

PF3D7_0612800 (P12p)

Genome location: Pf3D7_06_v3:527,873..529,438(-)

Genome classification: Core

Function and Localization

Product Description: 6-cysteine protein P12p

SignalP Peptide: MHIVSFIIFFFALFFPISIC

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0046658 anchored component of plasma membrane
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.11 0.94
Trophozoite no data 0.19 0.88
Schizont no data 0.07 0.95
Gametocyte no data 0.37 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0612800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.326 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0111100)

  • Relative Growth Rate: 0.72 ± 0.50
  • Confidence: 2.77

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1108700)

Modification: Disrupted | RMgm-5136

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSX1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532966

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 16 5 14
disruptive 31 44 19 43
missense 13 29 18 28

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 25 13 18
disruptive 48 96 35 105
missense 24 59 25 63

PlasmoDB Total SNPs: 118

Non-coding: 55 | Synonymous: 23 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 371 | Molecular Weight (kDa): 43.46

UniProt ID(s): C6KSX1

PDB ID(s): 7KJ7, 7KJH

Isoelectric Point: 5.8

Protein Domain Annotations:

Source Family ID Description
InterPro IPR010884 6-Cysteine (6-Cys) domain
PFam PF07422 6-Cysteine (6-Cys) domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16603573 Identification and stoichiometry of glycosylphosphatidylinositol-anchoredmembrane proteins of the human malaria parasite Plasmodium falciparum. Gilson PR, Nebl T, ..., Crabb BS 10.1074/mcp.M600035-MCP200
27128092 Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. Swearingen KE, Lindner SE, ..., Sinnis P 10.1371/journal.ppat.1005606