Product Description: 50S ribosomal protein L18, apicoplast, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005840 | ribosome |
| Function | GO:0008097 | 5S rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0042254 | ribosome biogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.39 | 0.76 |
| Schizont | expressed | 0.55 | 0.67 |
| Gametocyte | expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0613400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.259 | MFS: -2.633 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q6LFD5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 7 | 16 |
| disruptive | 1 | 10 | 8 | 16 |
| missense | 1 | 7 | 8 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 22 | 9 | 18 |
| disruptive | 3 | 27 | 14 | 29 |
| missense | 1 | 23 | 10 | 25 |
PlasmoDB Total SNPs: 48
Non-coding: 42 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 213 | Molecular Weight (kDa): 24.709
UniProt ID(s): Q6LFD5
PDB ID(s): None
Isoelectric Point: 10.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005484 | Ribosomal protein L18 |
| PFam | PF00861 | Ribosomal protein L18 |
| Superfamily | SSF53137 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |