PF3D7_0613500

Genome location: Pf3D7_06_v3:547,900..552,544(-)

Genome classification: Core

Function and Localization

Product Description: AP-3 complex subunit beta, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030123	AP-3 adaptor complex
Component	GO:0030135	coated vesicle
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	possibly expressed	0.34	0.79
Schizont	not expressed	0.20	0.87
Gametocyte	possibly expressed	0.60	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0613500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.089 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSX7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101595

Most Similar Human Ortholog: F5GWU4

TM-align score: 0.91 | RMSD: 1.68

Seq Identity: 0.36 | Length: 193 / 1363

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000103723	adaptor related protein complex 3 subunit beta 2
ENSG00000132842	adaptor related protein complex 3 subunit beta 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	21	52	31	83
disruptive	44	123	70	191
missense	18	93	60	155

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	110	48	90
disruptive	71	270	121	359
missense	31	204	89	239

PlasmoDB Total SNPs: 273

Non-coding: 19 | Synonymous: 155 | Nonsynonymous: 98 | Stop Codon: 1

Protein Information

Protein Length: 1363 | Molecular Weight (kDa): 159.775

UniProt ID(s): C6KSX7

PDB ID(s): None

Isoelectric Point: 6.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR026739	AP complex subunit beta
InterPro	IPR026740	AP-3 complex subunit beta
PFam	PF01602	Clathrin/coatomer adaptor, adaptin-like, N-terminal
Superfamily	SSF101967	Armadillo-type fold
Superfamily	SSF48371