About Gene List

PF3D7_0613700

Genome location: Pf3D7_06_v3:558,835..562,741(-)

Genome classification: Core

Function and Localization

Product Description: syntaxin-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Component GO:0005886 plasma membrane
Component GO:0030141 secretory granule
Function GO:0019905 syntaxin binding
Process GO:0006886 intracellular protein transport
Process GO:0009306 protein secretion
Process GO:0006904 vesicle docking involved in exocytosis
Process GO:0016192 vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.12 0.94
Trophozoite expressed 0.73 0.59
Schizont expressed 0.75 0.60
Gametocyte expressed 0.70 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0613700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.048 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSX9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100816

Most Similar Human Ortholog: A0A0D9SEP9

TM-align score: 0.94 | RMSD: 0.99

Seq Identity: 0.30 | Length: 100 / 703

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000076944 syntaxin binding protein 2
ENSG00000136854 syntaxin binding protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 39 14 48
disruptive 6 40 31 84
missense 5 35 30 76

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 69 25 47
disruptive 24 100 48 144
missense 11 84 42 105

PlasmoDB Total SNPs: 197

Non-coding: 145 | Synonymous: 39 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 703 | Molecular Weight (kDa): 82.768

UniProt ID(s): C6KSX9

PDB ID(s): None

Isoelectric Point: 6.53

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001619 Sec1-like protein
InterPro IPR036045 Sec1-like superfamily
PFam PF00995 Sec1-like protein
Superfamily SSF56815 Sec1-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108