PF3D7_0614100

Genome location: Pf3D7_06_v3:589,090..592,978(-)

Genome classification: Core

Function and Localization

Product Description: filamin domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	expressed	0.26	0.85
Schizont	expressed	1.01	0.51
Gametocyte	expressed	0.59	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0614100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.148 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4H5

"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=0.67) with 4LXQ (Global RMSD=17.95)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533172

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	24	17	30
disruptive	58	114	47	132
missense	38	79	35	100

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	49	19	59
disruptive	102	195	115	240
missense	60	134	88	158

PlasmoDB Total SNPs: 255

Non-coding: 136 | Synonymous: 69 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 935 | Molecular Weight (kDa): 112.567

UniProt ID(s): C0H4H5

PDB ID(s): None

Isoelectric Point: 8.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR017868	Filamin/ABP280 repeat-like
PFam	PF00630	Filamin/ABP280 repeat-like
Superfamily	SSF81296	Immunoglobulin E-set