Product Description: cytosolic Fe-S cluster assembly factor NAR1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.12.7.2 (Ferredoxin hydrogenase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Function | GO:0051536 | iron-sulfur cluster binding |
| Process | GO:0016226 | iron-sulfur cluster assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.35 | 0.83 |
| Trophozoite | expressed | 0.40 | 0.77 |
| Schizont | expressed | 0.18 | 0.88 |
| Gametocyte | expressed | 0.37 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0614200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.104 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSY3
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.12.7.2 | ferredoxin hydrogenase | O2COEDTACuSO4TironTris-HClProcion red2,2'-bipyridylethylene glycolSodium mersalylo-phenanthrolineguanidine hydrochloride... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101268
Most Similar Human Ortholog: H3BSH2
TM-align score: 0.90 | RMSD: 1.96
Seq Identity: 0.29 | Length: 182 / 910
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103245 | cytosolic iron-sulfur assembly component 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 27 | 13 | 53 |
| disruptive | 55 | 165 | 80 | 168 |
| missense | 25 | 103 | 59 | 129 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 58 | 42 | 68 |
| disruptive | 101 | 306 | 135 | 247 |
| missense | 42 | 205 | 99 | 181 |
PlasmoDB Total SNPs: 120
Non-coding: 3 | Synonymous: 43 | Nonsynonymous: 73 | Stop Codon: 1
Protein Length: 910 | Molecular Weight (kDa): 107.918
UniProt ID(s): C6KSY3
PDB ID(s): None
Isoelectric Point: 5.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004108 | Iron hydrogenase, large subunit, C-terminal |
| InterPro | IPR009016 | Iron hydrogenase |
| PFam | PF02906 | Iron hydrogenase, large subunit, C-terminal |
| Superfamily | SSF53920 | Iron hydrogenase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 25490157 | EPR monitored redox titration of the cofactors of Saccharomyces cerevisiae Nar1 | Hagedoorn PL, van der Weel L, Hagen WR | 10.3791/51611 |
| 24363367 | Molecular components of nitrate and nitrite efflux in yeast | Cabrera E, Gonzalez-Montelongo R, ..., Siverio JM | 10.1128/EC.00268-13 |
| 27818654 | Four Inducible Promoters for Controlled Gene Expression in the Oleaginous YeastRhodotorula toruloides | Johns AM, Love J, Aves SJ | 10.3389/fmicb.2016.01666 |