Product Description: major facilitator superfamily-related transporter, putative
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.32 | 0.85 |
| Trophozoite | expressed | 0.98 | 0.50 |
| Schizont | expressed | 0.74 | 0.59 |
| Gametocyte | expressed | 0.42 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0614300
Resistome Missense Mutations: S110F
Resistome Compounds with Missense Mutations: 3-Hydroxypropanamidine 22
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.977 | MFS: -1.479 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0112500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_0112500)
Modification: Tagged | RMgm-4345
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSY4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101629
Most Similar Human Ortholog: H3BP14
TM-align score: 0.86 | RMSD: 2.02
Seq Identity: 0.24 | Length: 140 / 853
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000169682 | sphingolipid transporter 1 (putative) |
| ENSG00000183018 | sphingolipid transporter 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 38 | 20 | 49 |
| disruptive | 11 | 67 | 31 | 93 |
| missense | 6 | 56 | 28 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 80 | 37 | 61 |
| disruptive | 27 | 150 | 78 | 194 |
| missense | 16 | 116 | 65 | 137 |
PlasmoDB Total SNPs: 320
Non-coding: 268 | Synonymous: 31 | Nonsynonymous: 20 | Stop Codon: 1
Protein Length: 853 | Molecular Weight (kDa): 96.98
UniProt ID(s): C6KSY4
PDB ID(s): None
Isoelectric Point: 7.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011701 | Major facilitator superfamily |
| InterPro | IPR036259 | MFS transporter superfamily |
| PFam | PF07690 | Major facilitator superfamily |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 21389117 | Mes1 controls the meiosis I to meiosis II transition by distinctly regulating theanaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fissionyeast | Kimata Y, Kitamura K, Fenner N, Yamano H | 10.1091/mbc.E10-09-0774 |
| 11405625 | A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation inSchizosaccharomyces pombe | Asakawa H, Kitamura K, Shimoda C | 10.1007/s004380000429 |
| 11493649 | Fission yeast mfr1 activates APC and coordinates meiotic nuclear division withsporulation | Blanco MA, Pelloquin L, Moreno S | 10.1242/jcs.114.11.2135 |