Product Description: 60S ribosomal protein L19
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.57 | 0.39 |
| Trophozoite | expressed | 2.15 | 0.18 |
| Schizont | expressed | 0.46 | 0.73 |
| Gametocyte | expressed | 0.90 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0614500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.036 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSY6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P0CX82 | 60S ribosomal protein L19-A | Saccharomyces cerevisiae | OMA, OrthoDB | cid_649707MLS000027148AKOS002484993MLS000082215... |
Ortholog Group (OrthoMCL): OG6_100773
Most Similar Human Ortholog: P84098
TM-align score: 0.98 | RMSD: 0.76
Seq Identity: 0.59 | Length: 182 / 182
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108298 | ribosomal protein L19 |
Protein Length: 182 | Molecular Weight (kDa): 21.58
UniProt ID(s): C6KSY6
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000196 | Ribosomal protein L19/L19e |
| InterPro | IPR033935 | Ribosomal protein L19, eukaryotic |
| InterPro | IPR035970 | Ribosomal protein L19/L19e superfamily |
| InterPro | IPR039547 | 60S ribosomal protein L19 |
| PFam | PF01280 | Ribosomal protein L19/L19e |
| Superfamily | SSF48140 | Ribosomal protein L19/L19e superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 101
Non-coding: 96 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 37358794 | RNA sequencing reveals the mechanism of FTO in inhibiting inflammation andexcessive proliferation of lipopolysaccharide-induced human glomerular mesangialcells | Zhuang X, Liu T, ..., Gao J | 10.1007/s00210-023-02570-x |