PF3D7_0614600

Genome location: Pf3D7_06_v3:609,088..611,451(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.05	0.97
Schizont	no data	0.45	0.77
Gametocyte	no data	0.93	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0614600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.144 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSY7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532496

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	19	14	28
disruptive	10	43	29	75
missense	9	35	24	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	44	23	54
disruptive	33	160	71	174
missense	14	106	45	106

PlasmoDB Total SNPs: 101

Non-coding: 42 | Synonymous: 52 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 614 | Molecular Weight (kDa): 74.444

UniProt ID(s): C6KSY7

PDB ID(s): None

Isoelectric Point: 9.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A