PF3D7_0614700

Genome location: Pf3D7_06_v3:612,082..614,491(+)

Genome classification: Core

Function and Localization

Product Description: F-box protein FBXO6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.03	0.98
Trophozoite	no data	0.04	0.98
Schizont	no data	0.55	0.73
Gametocyte	no data	0.69	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0614700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.208 | MFS: -2.728 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSY8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533410

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	26	12	41
disruptive	9	53	30	93
missense	6	43	24	67

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	53	22	56
disruptive	31	123	106	221
missense	16	89	66	114

PlasmoDB Total SNPs: 156

Non-coding: 102 | Synonymous: 36 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 604 | Molecular Weight (kDa): 72.444

UniProt ID(s): C6KSY8

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001810	F-box domain
InterPro	IPR036047	F-box-like domain superfamily
PFam	PF00646	F-box domain
Superfamily	SSF81383	F-box-like domain superfamily