Product Description: endonuclease III-like protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.2.2.- (Hydrolyzing N-glycosyl compounds.);4.2.99.18 (DNA-(apurinic or apyrimidinic site) lyase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005634 | nucleus |
Function | GO:0003906 | DNA-(apurinic or apyrimidinic site) endonuclease activity |
Function | GO:0004519 | endonuclease activity |
Function | GO:0000703 | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity |
Process | GO:0006281 | DNA repair |
Process | GO:0006285 | base-excision repair, AP site formation |
Process | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | possibly expressed | 0.14 | 0.93 |
Trophozoite | expressed | 0.66 | 0.64 |
Schizont | expressed | 0.19 | 0.87 |
Gametocyte | expressed | 0.49 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0614800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.997 | MFS: -2.991 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSY9
"Best" AlphaFill ligand hit: MBO (mercuribenzoic acid, Local RMSD=0.63) with 2JHN (Global RMSD=8.20)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100563
Most Similar Human Ortholog: A0A494BZZ6
TM-align score: 0.95 | RMSD: 1.06
Seq Identity: 0.45 | Length: 205 / 437
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000065057 | nth like DNA glycosylase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 1 | 17 | 10 | 27 |
disruptive | 27 | 50 | 33 | 85 |
missense | 13 | 38 | 27 | 68 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 31 | 18 | 33 |
disruptive | 42 | 126 | 60 | 129 |
missense | 22 | 84 | 43 | 94 |
PlasmoDB Total SNPs: 118
Non-coding: 62 | Synonymous: 25 | Nonsynonymous: 31 | Stop Codon: 0
Protein Length: 437 | Molecular Weight (kDa): 51.539
UniProt ID(s): C6KSY9
PDB ID(s): None
Isoelectric Point: 9.95
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000445 | Helix-hairpin-helix motif |
InterPro | IPR003265 | HhH-GPD domain |
InterPro | IPR003583 | Helix-hairpin-helix DNA-binding motif, class 1 |
InterPro | IPR003651 | Endonuclease III-like, iron-sulphur cluster loop motif |
InterPro | IPR004035 | Endonuclease III, iron-sulphur binding site |
InterPro | IPR004036 | Endonuclease III-like, conserved site-2 |
InterPro | IPR011257 | DNA glycosylase |
InterPro | IPR030841 | Endonuclease III-like protein 1 |
PFam | PF00633 | Helix-hairpin-helix motif |
PFam | PF00730 | HhH-GPD domain |
Superfamily | SSF48150 | DNA glycosylase |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |