About Gene List

PF3D7_0614900

Genome location: Pf3D7_06_v3:617,589..622,087(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.13 0.94
Trophozoite expressed 0.78 0.60
Schizont expressed 1.02 0.47
Gametocyte expressed 1.00 0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0614900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -1.558 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1229600)

  • Relative Growth Rate: 0.78 ± 0.17
  • Confidence: 4.96

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1229600)

Modification: Disrupted | RMgm-3315

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSZ0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105649

Most Similar Human Ortholog: Q9H330

TM-align score: 0.40 | RMSD: 6.07

Seq Identity: 0.18 | Length: 435 / 1096

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000106771 transmembrane protein 245

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 50 23 67
disruptive 26 81 52 152
missense 19 68 47 116

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 115 47 65
disruptive 69 217 124 294
missense 39 151 98 158

PlasmoDB Total SNPs: 160

Non-coding: 96 | Synonymous: 35 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 1096 | Molecular Weight (kDa): 130.934

UniProt ID(s): C6KSZ0

PDB ID(s): None

Isoelectric Point: 10.22

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002549 Transmembrane protein TqsA-like
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095