PF3D7_0615000

Genome location: Pf3D7_06_v3:622,098..623,014(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.39	0.81
Trophozoite	expressed	0.21	0.87
Schizont	expressed	0.07	0.96
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0615000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.138 | MFS: -3.339 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSZ1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533235

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	5	7	8
disruptive	6	16	12	27
missense	6	15	9	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	13	12	7
disruptive	12	49	16	40
missense	8	39	12	28

PlasmoDB Total SNPs: 70

Non-coding: 56 | Synonymous: 10 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 146 | Molecular Weight (kDa): 17.215

UniProt ID(s): C6KSZ1

PDB ID(s): None

Isoelectric Point: 4.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A