PF3D7_0615200

Genome location: Pf3D7_06_v3:625,120..627,612(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0045177	apical part of cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.07	0.96
Schizont	no data	0.07	0.96
Gametocyte	no data	0.89	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0615200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.968 | MFS: 0.018 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1229900)

Relative Growth Rate: 1.03 ± 0.12
Confidence: 5.68

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1229900)

Modification: Disrupted | RMgm-3316

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSZ3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148539

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	6	20
disruptive	10	27	30	50
missense	8	23	27	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	21	11	25
disruptive	19	82	37	86
missense	9	62	33	59

PlasmoDB Total SNPs: 211

Non-coding: 186 | Synonymous: 17 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 377 | Molecular Weight (kDa): 45.769

UniProt ID(s): C6KSZ3

PDB ID(s): None

Isoelectric Point: 9.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
29269729	A conserved ankyrin repeat-containing protein regulates conoid stability,motility and cell invasion in Toxoplasma gondii.	Long S, Anthony B, Drewry LL, Sibley LD	10.1038/s41467-017-02341-2