Product Description: GPI-anchored wall transfer protein 1, putative
SignalP Peptide: MSNMNILAYLLICPFNLIYI
# Transmembrane Domains: 13
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
| Function | GO:0032216 | glucosaminyl-phosphatidylinositol O-acyltransferase activity |
| Process | GO:0006506 | GPI anchor biosynthetic process |
| Process | GO:0072659 | protein localization to plasma membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.67 | 0.63 |
| Schizont | expressed | 0.24 | 0.85 |
| Gametocyte | expressed | 0.89 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0615300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.133 | MFS: -2.898 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1230000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1230000)
Modification: Disrupted | RMgm-3317
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSZ4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103051
Most Similar Human Ortholog: Q7Z7B1
TM-align score: 0.71 | RMSD: 4.45
Seq Identity: 0.20 | Length: 421 / 874
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000275600 | phosphatidylinositol glycan anchor biosynthesis class W |
| ENSG00000277161 | phosphatidylinositol glycan anchor biosynthesis class W |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 37 | 17 | 40 |
| disruptive | 56 | 74 | 36 | 102 |
| missense | 40 | 58 | 30 | 76 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 56 | 31 | 61 |
| disruptive | 98 | 146 | 78 | 186 |
| missense | 59 | 103 | 53 | 121 |
PlasmoDB Total SNPs: 114
Non-coding: 12 | Synonymous: 33 | Nonsynonymous: 69 | Stop Codon: 0
Protein Length: 874 | Molecular Weight (kDa): 105.757
PDB ID(s): None
Isoelectric Point: 9.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009447 | Phosphatidylinositol anchor biosynthesis protein PIGW/GWT1 |
| PFam | PF06423 | Phosphatidylinositol anchor biosynthesis protein PIGW/GWT1 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 35222844 | Compounds targeting GPI biosynthesis or N-glycosylation are active againstPlasmodium falciparum | Fenollar A, Ros-Lucas A, ..., Izquierdo L | 10.1016/j.csbj.2022.01.029 |
| 38205999 | In vitro activity of manogepix and comparators against infrequently encounteredyeast and mold isolates from the SENTRY Surveillance Program (2017-2022) | Pfaller M, Huband M, ..., Castanheira M | 10.1128/aac.01132-23 |