Product Description: ribonuclease, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 3.1.13.1 (Exoribonuclease II)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000932 | P-body |
| Component | GO:0000178 | exosome (RNase complex) |
| Component | GO:0005634 | nucleus |
| Function | GO:0000175 | 3'-5'-exoribonuclease activity |
| Function | GO:0004540 | ribonuclease activity |
| Process | GO:0006396 | RNA processing |
| Process | GO:0006402 | mRNA catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.12 | 0.54 |
| Trophozoite | expressed | 1.90 | 0.24 |
| Schizont | expressed | 1.15 | 0.50 |
| Gametocyte | expressed | 1.62 | 0.31 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0615400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.185 | MFS: -2.772 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.13.1 | exoribonuclease II | SDSEDTArRNAsucrosePoly(U)Poly(G)sperminepoly(dC)nicotinamidetrichostatin A5'-capped mRNAds plasmid DNA... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 56 | 141 | 58 | 179 |
| disruptive | 259 | 428 | 211 | 539 |
| missense | 119 | 278 | 157 | 390 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 84 | 252 | 118 | 201 |
| disruptive | 436 | 802 | 375 | 791 |
| missense | 188 | 542 | 265 | 504 |
PlasmoDB Total SNPs: 820
Non-coding: 369 | Synonymous: 222 | Nonsynonymous: 227 | Stop Codon: 2
Protein Length: 2729 | Molecular Weight (kDa): 323.2
UniProt ID(s): C6KSZ5
PDB ID(s): None
Isoelectric Point: 9.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001900 | Ribonuclease II/R |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR022966 | Ribonuclease II/R, conserved site |
| InterPro | IPR041505 | Dis3-like cold-shock domain 2 |
| PFam | PF00773 | Ribonuclease II/R |
| PFam | PF17849 | Dis3-like cold-shock domain 2 |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |