PF3D7_0615600

Genome location: Pf3D7_06_v3:646,286..655,848(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030687	preribosome, large subunit precursor
Function	GO:0019843	rRNA binding
Process	GO:0000027	ribosomal large subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.89	0.61
Trophozoite	expressed	1.07	0.46
Schizont	expressed	0.47	0.72
Gametocyte	expressed	0.79	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0615600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.823 | #Insertions: 6

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1230300)

Relative Growth Rate: 0.90 ± 0.18
Confidence: 4.82

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1230300)

Modification: Disrupted | RMgm-3319

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSZ7

"Best" AlphaFill ligand hit: 646 (2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-n-(1,3,5-trimethyl-1h-pyrazol-4-yl)benzenesulfonamide, Local RMSD=5.68) with 6MAZ (Global RMSD=13.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105606

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	32	100	59	139
disruptive	124	322	183	419
missense	80	278	162	375

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	54	179	94	161
disruptive	204	657	313	565
missense	125	552	264	445

PlasmoDB Total SNPs: 471

Non-coding: 180 | Synonymous: 156 | Nonsynonymous: 135 | Stop Codon: 0

Protein Information

Protein Length: 2528 | Molecular Weight (kDa): 304.062

UniProt ID(s): C6KSZ7

PDB ID(s): None

Isoelectric Point: 6.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF57850	N/A