PF3D7_0615800 (COG4)

Genome location: Pf3D7_06_v3:657,706..662,270(-)

Genome classification: Core

Function and Localization

Product Description: conserved oligomeric Golgi complex subunit 4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.37	0.77
Schizont	expressed	0.28	0.82
Gametocyte	expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0615800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.915 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1230600)

Relative Growth Rate: 0.07 ± 0.18
Confidence: 4.81

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSZ9

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.29) with 8P20 (Global RMSD=20.72)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102876

Most Similar Human Ortholog: H3BQB2

TM-align score: 0.81 | RMSD: 2.47

Seq Identity: 0.20 | Length: 138 / 1185

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000103051	component of oligomeric golgi complex 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	55	30	78
disruptive	34	121	82	217
missense	18	103	75	171

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	115	59	81
disruptive	66	265	162	339
missense	37	206	136	253

PlasmoDB Total SNPs: 204

Non-coding: 106 | Synonymous: 70 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 1185 | Molecular Weight (kDa): 141.14

UniProt ID(s): C6KSZ9

PDB ID(s): None

Isoelectric Point: 6.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A