PF3D7_0615900

Genome location: Pf3D7_06_v3:662,372..669,026(-)

Genome classification: Core

Function and Localization

Product Description: protein phosphatase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0615900

Resistome Missense Mutations: K633E

Resistome Compounds with Missense Mutations: AN13762, MMV665928

Resistome # Samples with Disruptive Mutations: 5 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.846 | #Insertions: 16

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1406900)

• Relative Growth Rate: 0.08 ± 0.10
• Confidence: 6.09

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1230700)

Modification: Disrupted | RMgm-3320

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K895

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110485

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 387

Non-coding: 117 | Synonymous: 158 | Nonsynonymous: 112 | Stop Codon: 0

Protein Information

Protein Length: 1806 | Molecular Weight (kDa): 220.02

UniProt ID(s): A0A5K1K895

PDB ID(s): None

Isoelectric Point: 9.93

Protein Domain Annotations: