PF3D7_0616300

Genome location: Pf3D7_06_v3:676,559..677,881(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.26	0.87
Trophozoite	no data	0.43	0.75
Schizont	no data	0.08	0.95
Gametocyte	no data	0.50	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0616300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.956 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT04

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533010

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	5	23
disruptive	9	16	11	41
missense	3	14	10	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	23	10	19
disruptive	12	42	27	78
missense	5	36	21	54

PlasmoDB Total SNPs: 72

Non-coding: 58 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 227 | Molecular Weight (kDa): 26.901

UniProt ID(s): C6KT04

PDB ID(s): None

Isoelectric Point: 9.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A