PF3D7_0616400

Genome location: Pf3D7_06_v3:678,087..684,110(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MPFYLSFFLLLVYNIVIKVYG

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.23	0.89
Trophozoite	expressed	0.52	0.70
Schizont	expressed	0.21	0.87
Gametocyte	not expressed	0.38	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0616400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.131 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1115900)

Relative Growth Rate: 0.10 ± 0.08
Confidence: 6.42

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT05

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.70) with 3MMR (Global RMSD=14.84)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532479

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	57	30	82
disruptive	129	272	132	342
missense	73	217	113	292

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	110	53	100
disruptive	195	592	236	494
missense	105	450	181	341

PlasmoDB Total SNPs: 323

Non-coding: 89 | Synonymous: 111 | Nonsynonymous: 120 | Stop Codon: 3

Protein Information

Protein Length: 1680 | Molecular Weight (kDa): 205.004

UniProt ID(s): C6KT05

PDB ID(s): None

Isoelectric Point: 9.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895