Product Description: TRAP-like protein
SignalP Peptide: MNAPYPLVCLALWLLFLLDVRKC
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0048870 | cell motility |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.02 | 0.99 |
| Trophozoite | no data | 0.02 | 0.99 |
| Schizont | no data | 0.03 | 0.98 |
| Gametocyte | no data | 0.36 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0616500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.179 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1116000)
Modification: Disrupted | RMgm-5107
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT06
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 74 | 44 | 89 |
| disruptive | 109 | 238 | 111 | 256 |
| missense | 69 | 174 | 96 | 201 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 146 | 50 | 102 |
| disruptive | 167 | 424 | 168 | 340 |
| missense | 105 | 326 | 134 | 238 |
PlasmoDB Total SNPs: 246
Non-coding: 0 | Synonymous: 118 | Nonsynonymous: 128 | Stop Codon: 0
Protein Length: 1371 | Molecular Weight (kDa): 160.119
UniProt ID(s): C6KT06
PDB ID(s): None
Isoelectric Point: 4.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| InterPro | IPR002035 | von Willebrand factor, type A |
| InterPro | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| InterPro | IPR036465 | von Willebrand factor A-like domain superfamily |
| PFam | PF00090 | Thrombospondin type-1 (TSP1) repeat |
| Superfamily | SSF53300 | von Willebrand factor A-like domain superfamily |
| Superfamily | SSF82895 | Thrombospondin type-1 (TSP1) repeat superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18441124 | Functional characterization of a redundant Plasmodium TRAP family invasin,TRAP-like protein, by aldolase binding and a genetic complementation test. | Heiss K, Nie H, ..., Matuschewski K | 10.1128/EC.00089-08 |