About Gene List

PF3D7_0616600

Genome location: Pf3D7_06_v3:689,086..691,142(-)

Genome classification: Core

Function and Localization

Product Description: HROB domain-containing protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite expressed 0.42 0.75
Schizont expressed 0.29 0.81
Gametocyte expressed 0.46 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0616600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.235 | MFS: -2.906 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1116100)

  • Relative Growth Rate: 0.94 ± 0.10
  • Confidence: 5.94

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1116100)

Modification: Disrupted | RMgm-3014

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT07

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107451

Most Similar Human Ortholog: Q8N3J3

TM-align score: 0.26 | RMSD: 6.33

Seq Identity: 0.19 | Length: 218 / 625

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000125319 homologous recombination factor with OB-fold

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 24 12 37
disruptive 52 133 52 127
missense 19 80 39 93

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 53 23 39
disruptive 100 225 88 163
missense 43 145 63 114

PlasmoDB Total SNPs: 141

Non-coding: 40 | Synonymous: 60 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 625 | Molecular Weight (kDa): 73.9

UniProt ID(s): C6KT07

PDB ID(s): None

Isoelectric Point: 8.97

Protein Domain Annotations:

Source Family ID Description
InterPro IPR028045 Homologous recombination OB-fold protein
PFam PF15072 Homologous recombination OB-fold protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104