PF3D7_0616900

Genome location: Pf3D7_06_v3:698,792..704,220(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.51	0.76
Trophozoite	expressed	0.87	0.54
Schizont	expressed	0.24	0.86
Gametocyte	expressed	0.74	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0616900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.902 | MFS: -0.607 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1116400)

Relative Growth Rate: 0.09 ± 0.21
Confidence: 4.50

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT10

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532984

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	48	39	76
disruptive	48	189	121	283
missense	38	172	115	253

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	104	65	78
disruptive	104	420	191	408
missense	70	361	165	281

PlasmoDB Total SNPs: 181

Non-coding: 66 | Synonymous: 52 | Nonsynonymous: 62 | Stop Codon: 1

Protein Information

Protein Length: 1321 | Molecular Weight (kDa): 158.666

UniProt ID(s): C6KT10

PDB ID(s): None

Isoelectric Point: 6.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A